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GPCR

NameMelanocortin receptor 5
SpeciesMus musculus (Mouse)
GeneMc5r
SynonymMC5 receptor
MC5-R
MC5R
melanocortin receptor 5
DiseaseN/A for non-human GPCRs
Length325
Amino acid sequenceMNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
UniProtP41149
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4489
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL138212
Molecular formulaC35H45N11O5
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-N-(2-amino-2-oxoethyl)-5-(diaminomethylideneamino)-N-[2-(1H-indol-3-yl)ethyl]pentanamide
Molecular weight699.817
Hydrogen bond acceptor7
Hydrogen bond donor8
XlogP0.1
SynonymsBDBM50136748
(S)-2-{(S)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid carbamoylmethyl-[2-(1H-indol-3-yl)-ethyl]-amide
Inchi KeyDNTXCPMOMVOUSI-DTXPUJKBSA-N
Inchi IDInChI=1S/C35H45N11O5/c1-22(47)43-30(17-25-19-39-21-42-25)33(50)45-29(16-23-8-3-2-4-9-23)32(49)44-28(12-7-14-40-35(37)38)34(51)46(20-31(36)48)15-13-24-18-41-27-11-6-5-10-26(24)27/h2-6,8-11,18-19,21,28-30,41H,7,12-17,20H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,49)(H,45,50)(H4,37,38,40)/t28-,29-,30-/m0/s1
PubChem CID44359731
ChEMBLCHEMBL138212
IUPHARN/A
BindingDB50136748
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5056.0 nMPMID14643357BindingDB,ChEMBL

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