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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL14361
Molecular formulaC23H25ClN2O4
IUPAC name1-[4-[2-[4-(6-chloro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethoxy]-3-methoxyphenyl]ethanone
Molecular weight428.913
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP4.3
SynonymsAITQIGCIBUOIAD-UHFFFAOYSA-N
1-[4-[2-[4-(6-Chloro-1,2-benzisoxazol-3-yl)-1piperidinyl]ethoxy]-3-methoxyphenyl]-ethanone
BDBM50034048
1-(4-{2-[4-(6-Chloro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethoxy}-3-methoxy-phenyl)-ethanone
SCHEMBL1545043
[ Show all ]
Inchi KeyAITQIGCIBUOIAD-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25ClN2O4/c1-15(27)17-3-6-20(22(13-17)28-2)29-12-11-26-9-7-16(8-10-26)23-19-5-4-18(24)14-21(19)30-25-23/h3-6,13-14,16H,7-12H2,1-2H3
PubChem CID10342570
ChEMBLCHEMBL14361
IUPHARN/A
BindingDB50034048
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50940.0 nMPMID7707315BindingDB,ChEMBL

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