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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL87370
Molecular formula	C20H16F3N3O
IUPAC name	(E)-N-(4-amino-2-methylquinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Molecular weight	371.363
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.1
Synonyms	BDBM50193649 N-(4-Amino-2-methyl-quinolin-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide (E)-N-(4-amino-2-methylquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide SCHEMBL6204654 (E)-N-(4-Amino-2-methyl-6-quinolinyl)-4-trifluoromethylcinnamamide SCHEMBL6204655 [ Show all ]
Inchi Key	DOZGFBDFGIPWCL-RUDMXATFSA-N
Inchi ID	InChI=1S/C20H16F3N3O/c1-12-10-17(24)16-11-15(7-8-18(16)25-12)26-19(27)9-4-13-2-5-14(6-3-13)20(21,22)23/h2-11H,1H3,(H2,24,25)(H,26,27)/b9-4+
PubChem CID	15133403
ChEMBL	CHEMBL87370
IUPHAR	N/A
BindingDB	50193649
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	140.0 nM	PMID16919453	BindingDB,ChEMBL
IC50	8.0 nM	PMID16919453	BindingDB,ChEMBL

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