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GPCR

NameMu-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRM1
SynonymhMOP
M-OR-1
MOP
opioid receptor, mu 1
opioid receptor
[ Show all ]
DiseaseDiarrhea
Inflammatory disease
Pain
Major depressive disorder
Migraine
[ Show all ]
Length400
Amino acid sequenceMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtP35372
Protein Data BankN/A
GPCR-HGmod modelP35372
3D structure modelThis predicted structure model is from GPCR-EXP P35372.
BioLiPN/A
Therapeutic Target DatabaseT47768
ChEMBLCHEMBL233
IUPHAR319
DrugBankBE0000770

Ligand

NameMLS000401592
Molecular formulaC26H21FN4O5S2
IUPAC name1-(4-fluorophenyl)-N-[2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]phenyl]-3-methylthieno[2,3-c]pyrazole-5-carboxamide
Molecular weight552.595
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP5.1
SynonymsAC1MVXLJ
1-(4-fluorophenyl)-N-[2-hydroxy-5-[(4-methoxyphenyl)sulfamoyl]phenyl]-3-methyl-5-thieno[2,3-c]pyrazolecarboxamide
SMR000243497
1-(4-fluorophenyl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-oxidanyl-phenyl]-3-methyl-thieno[2,3-c]pyrazole-5-carboxamide
HMS2536N23
[ Show all ]
Inchi KeyAIXCLGQVXMIORW-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H21FN4O5S2/c1-15-21-14-24(37-26(21)31(29-15)18-7-3-16(27)4-8-18)25(33)28-22-13-20(11-12-23(22)32)38(34,35)30-17-5-9-19(36-2)10-6-17/h3-14,30,32H,1-2H3,(H,28,33)
PubChem CID3690550
ChEMBLCHEMBL1587837
IUPHARN/A
BindingDB68066
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<92498.0 nMPubChem BioAssay data setChEMBL

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