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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Homo sapiens (Human)
Gene	PTGER1
Synonym	PGE receptor EP1 subtype EP1 receptor prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor EP1 prostanoid receptor PGE2 receptor EP1 subtype [ Show all ]
Disease	Unspecified Thrombosis Pollakiuria Pain
Length	402
Amino acid sequence	MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProt	P34995
Protein Data Bank	N/A
GPCR-HGmod model	P34995
3D structure model	This predicted structure model is from GPCR-EXP P34995.
BioLiP	N/A
Therapeutic Target Database	T15497
ChEMBL	CHEMBL1811
IUPHAR	340
DrugBank	BE0000064

Ligand

Name	CHEMBL313266
Molecular formula	C27H27NO4S4
IUPAC name	N-[2-[2-[4-(2-phenylethylsulfanylmethyl)phenyl]phenyl]ethylsulfonyl]thiophene-2-sulfonamide
Molecular weight	557.756
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	6.5
Synonyms	BDBM50117688 N-(2-Thienylsulfonyl)-2-[4'-(phenethylthiomethyl)-2-biphenylyl]ethanesulfonamide
Inchi Key	AIYVFZXYZSCMIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H27NO4S4/c29-35(30,28-36(31,32)27-11-6-18-34-27)20-17-24-9-4-5-10-26(24)25-14-12-23(13-15-25)21-33-19-16-22-7-2-1-3-8-22/h1-15,18,28H,16-17,19-21H2
PubChem CID	44320294
ChEMBL	CHEMBL313266
IUPHAR	N/A
BindingDB	50117688
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7500.0 nM	PMID12182865	BindingDB,ChEMBL

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