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GPCR

NameMetabotropic glutamate receptor 2
SpeciesRattus norvegicus (Rat)
GeneGrm2
Synonymglutamate receptor
GPRC1B
metabotropic glutamate receptor 2
mGlu2 receptor
mGluR2
DiseaseN/A for non-human GPCRs
Length872
Amino acid sequenceMESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtP31421
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2851
IUPHAR290
DrugBankN/A

Ligand

NameCHEMBL185423
Molecular formulaC17H18Cl2FNO5
IUPAC name(1R,2R,3R,5R,6R)-2-amino-3-[(1S)-1-(3,4-dichlorophenyl)propoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular weight406.231
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP0.3
Synonyms(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-propoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
BDBM50151445
Inchi KeyDQUWONNIKAVHTA-WZJDNFATSA-N
Inchi IDInChI=1S/C17H18Cl2FNO5/c1-2-11(7-3-4-9(18)10(19)5-7)26-12-6-8-13(16(8,20)14(22)23)17(12,21)15(24)25/h3-5,8,11-13H,2,6,21H2,1H3,(H,22,23)(H,24,25)/t8-,11+,12-,13+,16-,17+/m1/s1
PubChem CID11177217
ChEMBLCHEMBL185423
IUPHARN/A
BindingDB50151445
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.12 nMPMID15317467ChEMBL

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