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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | thiazole, 29 |
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Molecular formula | C28H22ClF3N2O4S |
IUPAC name | 3-[[4-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-2-[4-(trifluoromethoxy)phenyl]ethyl]benzoyl]amino]propanoic acid |
Molecular weight | 574.999 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 6.9 |
Synonyms | 3-{4-[2-[4-(4-Chlorophenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]-benzoylamino}propionic Acid SCHEMBL2648554 3-{4-[2-[4-(4-chlorophenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoylamino}propionic acid CHEMBL493020 BDBM29132 [ Show all ] |
Inchi Key | DRBYFBHVRFFBIU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H22ClF3N2O4S/c29-21-9-5-19(6-10-21)24-16-39-27(34-24)23(18-7-11-22(12-8-18)38-28(30,31)32)15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36) |
PubChem CID | 22496448 |
ChEMBL | CHEMBL493020 |
IUPHAR | N/A |
BindingDB | 29132 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 98.0 nM | PMID19385613 | BindingDB,ChEMBL |
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