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Name | 5-hydroxytryptamine receptor 1D |
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Species | Sus scrofa (Pig) |
Gene | HTR1D |
Synonym | 5-HT-1D 5-HT1D Serotonin receptor 1D |
Disease | N/A for non-human GPCRs |
Length | 291 |
Amino acid sequence | AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV |
UniProt | P79400 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4105 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL65669 |
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Molecular formula | C20H20N4S |
IUPAC name | 8-(4-methylpiperazin-1-yl)-4-phenyl-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene |
Molecular weight | 348.468 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 4.8 |
Synonyms | BDBM50407788 SCHEMBL7301516 |
Inchi Key | DRJDHULKURBTLQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H20N4S/c1-22-10-12-23(13-11-22)19-16-8-5-9-24(16)17-14-18(25-20(17)21-19)15-6-3-2-4-7-15/h2-9,14H,10-13H2,1H3 |
PubChem CID | 10665419 |
ChEMBL | CHEMBL65669 |
IUPHAR | N/A |
BindingDB | 50407788 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 60256.0 nM | PMID8642566 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218