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GPCR

NameMelatonin receptor type 1C
SpeciesGallus gallus (Chicken)
Gene
SynonymCKB
Mel-1C-R
Mel1c receptor
DiseaseN/A for non-human GPCRs
Length346
Amino acid sequenceMERPGSNGSCSGCRLEGGPAARAASGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLRYDKLFNLKNTCCYICLTWTLTVVAIVPNFFVGSLQYDPRIYSCTFAQTVSTSYTITVVVVHFIVPLSIVTFCYLRIWILVIQVKHRVRQDCKQKIRAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKVQPHIPEWLFVLSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILLMLRTPRLLFIDVSKGGTEGLKSKPSPAVTNNNQAEIHL
UniProtP49288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3196
IUPHARN/A
DrugBankN/A

Ligand

NameMelatonin
Molecular formulaC13H16N2O2
IUPAC nameN-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
Molecular weight232.283
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP0.8
SynonymsN-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
Spectrum2_001344
N-[2-(5-methoxyindol-3-yl)ethyl]-Acetamide
SR-01000075559-7
NCGC00015680-06
[ Show all ]
Inchi KeyDRLFMBDRBRZALE-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
PubChem CID896
ChEMBLCHEMBL45
IUPHAR224, 1357
BindingDB9019
DrugBankDB01065

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative affinity1.0 -PMID9748358ChEMBL

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