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Name | Adenosine receptor A1 |
---|---|
Species | Gallus gallus (Chicken) |
Gene | ADORA1 |
Synonym | N/A |
Disease | N/A for non-human GPCRs |
Length | 324 |
Amino acid sequence | MAQSVTAFQAAYISIEVLIALVSVPGNILVIWAVKMNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMMACPVLILTESSILALLAIAVDRYLRVKIPVRYKSVVTPRRAAVAIACCWIVSFLVGLTPMFGWNNLNKVLGTRDLNVSHSEFVIKCQFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFNLIRTQLNKKVSSSSNDPQKYYGKELKIAKSLALVLFLFALSWLPLHILNCITLFCPSCKTPHILTYIAIFLTHGNSAMNPIVYAFRIKKFRTAFLQIWNQYFCCKTNKSSSSSTAETVN |
UniProt | P49892 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2114 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL609650 |
---|---|
Molecular formula | C16H17N5O5 |
IUPAC name | (3R,4S,5R)-2-[6-(3-hydroxyanilino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
Molecular weight | 359.342 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 5 |
XlogP | 0.8 |
Synonyms | BDBM50367496 |
Inchi Key | DSKWJMPYHQTWFI-AARXTDBFSA-N |
Inchi ID | InChI=1S/C16H17N5O5/c22-5-10-12(24)13(25)16(26-10)21-7-19-11-14(17-6-18-15(11)21)20-8-2-1-3-9(23)4-8/h1-4,6-7,10,12-13,16,22-25H,5H2,(H,17,18,20)/t10-,12-,13-,16?/m1/s1 |
PubChem CID | 46877050 |
ChEMBL | CHEMBL609650 |
IUPHAR | N/A |
BindingDB | 50367496 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 11.1 nM | PMID3572985 | BindingDB,ChEMBL |
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