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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameBDBM50359423
Molecular formulaC20H24N4O2
IUPAC name1-hydroxy-2-[4-(quinolin-2-ylmethylamino)butyl]-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-one
Molecular weight352.438
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.8
SynonymsN/A
Inchi KeyDSMQQQLBFHYIQT-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24N4O2/c25-19-18-8-5-13-23(18)20(26)24(19)12-4-3-11-21-14-16-10-9-15-6-1-2-7-17(15)22-16/h1-2,6-7,9-10,21,25H,3-5,8,11-14H2
PubChem CID91143227
ChEMBLN/A
IUPHARN/A
BindingDB50359423
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID22029386BindingDB

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