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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameBDBM37655
Molecular formulaC22H17BrN2O4
IUPAC name5-(3-bromophenyl)-4-(4-methylbenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
Molecular weight453.292
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.2
Synonyms(4E)-5-(3-bromophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(5-methyl-3-isoxazolyl)pyrrolidine-2,3-dione
cid_5389438
(4E)-5-(3-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)-4-[(4-methylphenyl)-oxidanyl-methylidene]pyrrolidine-2,3-dione
(4E)-5-(3-bromophenyl)-4-[hydroxy(p-tolyl)methylene]-1-(5-methylisoxazol-3-yl)pyrrolidine-2,3-quinone
Inchi KeyAJCSMKLQIMMORL-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H17BrN2O4/c1-12-6-8-14(9-7-12)20(26)18-19(15-4-3-5-16(23)11-15)25(22(28)21(18)27)17-10-13(2)29-24-17/h3-11,18-19H,1-2H3
PubChem CID91896310
ChEMBLN/A
IUPHARN/A
BindingDB37655
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<43700.0 nMN/ABindingDB

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