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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	AM 281
Molecular formula	C21H19Cl2IN4O2
IUPAC name	1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
Molecular weight	557.213
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	FT-0752198 NCGC00025009-01 TRA0027415 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl- BN0064 J-013143 SBP4A4DYH2 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide AM281, >=98% (HPLC) D0UD9H MFCD01861180 SR-01000597389-1 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide AJFFBPZYXRNAIC-UHFFFAOYSA-N BCP07951 GTPL741 NCGC00025009-02 UNII-SBP4A4DYH2 202463-68-1 AM-281 BRD-K59419204-001-01-9 KB-309876 SCHEMBL1517458 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide AC1N7ICF B6603 CHEMBL476833 EX-A1546 MolPort-003-940-033 Tocris-1115 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl- AKOS024456391 BDBM50267372 HMS3267K18 RT-011256 ZINC2575699 1-(2,4-DICHLORO-PHENYL)-5-(4-IODO-PHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID MORPHOLIN-4-YL AMIDE AM281 CHEBI:93039 CTK8E9266 L023967 SR-01000597389 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide ACM202463681 BC600570 [ Show all ]
Inchi Key	AJFFBPZYXRNAIC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
PubChem CID	4302962
ChEMBL	CHEMBL476833
IUPHAR	741
BindingDB	50267372
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	2.0 %	PMID19278853	ChEMBL
Intrinsic activity	-42.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
Ki	4.5 nM	PMID12570386	ChEMBL
Ki	12.4 nM	PMID19278853	BindingDB,ChEMBL
Ki	12.6 nM	PMID11741201	IUPHAR

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