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GPCR

NameD(3) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd3
SynonymD3 receptor
D3R
Dopamine D3 receptor
dopaminergic receptor D3
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProtP19020
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3138
IUPHAR216
DrugBankN/A

Ligand

NameCHEMBL171519
Molecular formulaC14H15N3
IUPAC name(6aR,11aS)-6,6a,7,10,11,11a-hexahydro-5H-pyrazolo[3,4-b]phenanthridine
Molecular weight225.295
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP1.5
Synonyms(6aR)-6,6abeta,7,9,11,11aalpha-Hexahydro-6,9,10-triaza-5H-cyclopenta[b]phenanthrene
Inchi KeyAJFYLTMGDGJNDW-GXTWGEPZSA-N
Inchi IDInChI=1S/C14H15N3/c1-2-4-11-9(3-1)7-15-14-5-10-8-16-17-13(10)6-12(11)14/h1-4,8,12,14-15H,5-7H2,(H,16,17)/t12-,14+/m0/s1
PubChem CID10537192
ChEMBLCHEMBL171519
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
K 0.5955.0 nMPMID10072690ChEMBL

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