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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymD4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
d(2C) dopamine receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiv, 5wiu
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiv.
BioLiPBL0394824, BL0394826, BL0394825
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL105234
Molecular formulaC21H26ClNO2
IUPAC name4-[(4-chlorophenyl)methyl]-2-[(2-propylphenoxy)methyl]morpholine
Molecular weight359.894
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.1
SynonymsBDBM50147930
2-(2-Butyl-phenoxymethyl)-4-(4-chloro-benzyl)-morpholine
Inchi KeyAJIUZQXFIWGVET-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26ClNO2/c1-2-5-18-6-3-4-7-21(18)25-16-20-15-23(12-13-24-20)14-17-8-10-19(22)11-9-17/h3-4,6-11,20H,2,5,12-16H2,1H3
PubChem CID11360382
ChEMBLCHEMBL105234
IUPHARN/A
BindingDB50147930
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki32.0 nMPMID15163190BindingDB,ChEMBL

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