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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCID 69083551
Molecular formulaC24H29ClN6
IUPAC name2-[6-[[2-[2-(4-chlorophenyl)ethenyl]-6-methylquinazolin-4-yl]amino]hexyl]guanidine
Molecular weight436.988
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP5.0
SynonymsN/A
Inchi KeyAJJJEWSKZNVTFT-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H29ClN6/c1-17-6-12-21-20(16-17)23(28-14-4-2-3-5-15-29-24(26)27)31-22(30-21)13-9-18-7-10-19(25)11-8-18/h6-13,16H,2-5,14-15H2,1H3,(H4,26,27,29)(H,28,30,31)
PubChem CID69083551
ChEMBLN/A
IUPHARN/A
BindingDB26971
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki89.0 nMPMID19041249BindingDB

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