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Name | Metabotropic glutamate receptor 8 |
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Species | Homo sapiens (Human) |
Gene | GRM8 |
Synonym | mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor [ Show all ] |
Disease | N/A |
Length | 908 |
Amino acid sequence | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
UniProt | O00222 |
Protein Data Bank | 6bsz, 6bt5, 6e5v |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 6bsz. |
BioLiP | BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3228 |
IUPHAR | 296 |
DrugBank | BE0000835 |
Name | LY307452 |
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Molecular formula | C21H25NO4 |
IUPAC name | (2S,4S)-2-amino-4-(4,4-diphenylbutyl)pentanedioic acid |
Molecular weight | 355.434 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 1.4 |
Synonyms | (2S,4S)-2-amino-4-(4,4-diphenylbutyl)pentanedioic acid GTPL3350 AC1O44IF LY-307452 (2s,4s)-2-amino-4-(4,4-di-phenylbut-1-yl)-pentane-1,5-dioic acid [ Show all ] |
Inchi Key | DWLOVDOPFJPWNE-HKUYNNGSSA-N |
Inchi ID | InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1 |
PubChem CID | 6324634 |
ChEMBL | CHEMBL39338 |
IUPHAR | N/A |
BindingDB | 50049748 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <300000.0 nM | PMID9873471, PMID9871538 | BindingDB,ChEMBL |
Ki | <300000.0 nM | PMID10893301 | BindingDB,ChEMBL |
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