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Name | Alpha-1A adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA1A |
Synonym | alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c [ Show all ] |
Disease | Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma [ Show all ] |
Length | 466 |
Amino acid sequence | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV |
UniProt | P35348 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35348 |
3D structure model | This predicted structure model is from GPCR-EXP P35348. |
BioLiP | N/A |
Therapeutic Target Database | T92609 |
ChEMBL | CHEMBL229 |
IUPHAR | 22 |
DrugBank | BE0000501 |
Name | CHEMBL1651208 |
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Molecular formula | C27H24ClNO4 |
IUPAC name | 2-chloro-5-[3-[(2-cyclopentyl-1-oxo-3H-isoindol-5-yl)oxymethyl]phenyl]benzoic acid |
Molecular weight | 461.942 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.5 |
Synonyms | SCHEMBL787354 4-Chloro-3''-((2-cyclopentyl-1-oxoisoindolin-5-yloxy)methyl)-biphenyl-3-carboxylic Acid BDBM50335253 DWTYHCYVKJONSP-UHFFFAOYSA-N 4-Chloro-3'-((2-cyclopentyl-1-oxoisoindolin-5-yloxy)-methyl)biphenyl-3-carboxylic acid |
Inchi Key | DWTYHCYVKJONSP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H24ClNO4/c28-25-11-8-19(14-24(25)27(31)32)18-5-3-4-17(12-18)16-33-22-9-10-23-20(13-22)15-29(26(23)30)21-6-1-2-7-21/h3-5,8-14,21H,1-2,6-7,15-16H2,(H,31,32) |
PubChem CID | 46182745 |
ChEMBL | CHEMBL1651208 |
IUPHAR | N/A |
BindingDB | 50335253 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 8150.0 nM | PMID23009245 | BindingDB,ChEMBL |
Inhibition | 65.0 % | PMID23009245 | ChEMBL |
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