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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000394090
Molecular formula	C18H18N4O3S3
IUPAC name	N-[3-[methyl(phenyl)sulfamoyl]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
Molecular weight	434.547
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.2
Synonyms	HMS3375A14 SMR000247765 BDBM42066 MolPort-005-530-845 cid_15945356 N-[3-[methyl(phenyl)sulfamoyl]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]acetamide 920667-66-9 MCULE-7274731819 Z25102806 N-[3-[methyl(phenyl)sulfamoyl]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide HMS2513M14 N-{3-[methyl(phenyl)sulfamoyl]phenyl}-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide AKOS033932705 ZINC8692846 CHEMBL1570553 N-[3-[methyl(phenyl)sulfamoyl]phenyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanamide [ Show all ]
Inchi Key	DXCSCRTWZTXHLN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H18N4O3S3/c1-13-20-21-18(27-13)26-12-17(23)19-14-7-6-10-16(11-14)28(24,25)22(2)15-8-4-3-5-9-15/h3-11H,12H2,1-2H3,(H,19,23)
PubChem CID	15945356
ChEMBL	CHEMBL1570553
IUPHAR	N/A
BindingDB	42066
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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