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Name | Free fatty acid receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR2 |
Synonym | FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 [ Show all ] |
Disease | Abortion Diabetes |
Length | 330 |
Amino acid sequence | MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE |
UniProt | O15552 |
Protein Data Bank | N/A |
GPCR-HGmod model | O15552 |
3D structure model | This predicted structure model is from GPCR-EXP O15552. |
BioLiP | N/A |
Therapeutic Target Database | T28213 |
ChEMBL | CHEMBL5493 |
IUPHAR | 226 |
DrugBank | N/A |
Name | CHEMBL593435 |
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Molecular formula | C15H16ClN3O |
IUPAC name | (2S)-2-(4-chlorophenyl)-3-methyl-N-pyridazin-3-ylbutanamide |
Molecular weight | 289.763 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | BDBM50305954 (S)-2-(4-chlorophenyl)-3-methyl-N-(pyridazin-3-yl)butanamide |
Inchi Key | DYKQXHLDYNKKKR-AWEZNQCLSA-N |
Inchi ID | InChI=1S/C15H16ClN3O/c1-10(2)14(11-5-7-12(16)8-6-11)15(20)18-13-4-3-9-17-19-13/h3-10,14H,1-2H3,(H,18,19,20)/t14-/m0/s1 |
PubChem CID | 46226161 |
ChEMBL | CHEMBL593435 |
IUPHAR | N/A |
BindingDB | 50305954 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Efficacy | 101.0 % | PMID20005104 | ChEMBL |
IC50 | 2300.0 nM | PMID20005104 | BindingDB,ChEMBL |
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