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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

Name13474-65-2
Molecular formulaC13H16N2O2
IUPAC name2-[3-(dimethylamino)propyl]isoindole-1,3-dione
Molecular weight232.283
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP1.9
SynonymsDTXSID30504344
2-[3-(Dimethylamino)propyl]-1H-isoindole-1,3(2H)-dione
N-[3-(Dimethylamino)propyl]phthalimide
CHEMBL324165
1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)propyl]-
[ Show all ]
Inchi KeyDYZHJGYWAJRDAJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H16N2O2/c1-14(2)8-5-9-15-12(16)10-6-3-4-7-11(10)13(15)17/h3-4,6-7H,5,8-9H2,1-2H3
PubChem CID12612168
ChEMBLCHEMBL324165
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Emax,diss100.0 %PMID15163212ChEMBL
Palpha-0.45 -PMID15163212ChEMBL
pEC0.5,diss5.87 -PMID15163212ChEMBL
pKA6.43 -PMID15163212ChEMBL

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