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Name | Melanin-concentrating hormone receptor 1 |
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Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL384547 |
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Molecular formula | C23H20F3N3O |
IUPAC name | (E)-N-(4-amino-2-cyclobutylquinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-enamide |
Molecular weight | 411.428 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 4.8 |
Synonyms | SCHEMBL6204528 BDBM50193620 SCHEMBL6204521 (E)-N-(4-amino-2-cyclobutylquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide |
Inchi Key | DZBRSGDTRPYNOH-IZZDOVSWSA-N |
Inchi ID | InChI=1S/C23H20F3N3O/c24-23(25,26)16-7-4-14(5-8-16)6-11-22(30)28-17-9-10-20-18(12-17)19(27)13-21(29-20)15-2-1-3-15/h4-13,15H,1-3H2,(H2,27,29)(H,28,30)/b11-6+ |
PubChem CID | 44417947 |
ChEMBL | CHEMBL384547 |
IUPHAR | N/A |
BindingDB | 50193620 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 250.0 nM | PMID16919453 | BindingDB,ChEMBL |
IC50 | 2.0 nM | PMID16919453 | BindingDB,ChEMBL |
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