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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL355135
Molecular formulaC18H16BrN3O
IUPAC name1-(2-bromo-4-propan-2-ylphenyl)-4-methyl-6-oxo-7H-pyrrolo[2,3-b]pyridine-3-carbonitrile
Molecular weight370.25
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP3.5
Synonyms1-(2-Bromo-4-isopropyl-phenyl)-6-hydroxy-4-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
BDBM50074416
1-(2-Bromo-4-isopropylphenyl)-4-methyl-6-hydroxy-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
Inchi KeyDZHYYJXOBIBELN-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H16BrN3O/c1-10(2)12-4-5-15(14(19)7-12)22-9-13(8-20)17-11(3)6-16(23)21-18(17)22/h4-7,9-10H,1-3H3,(H,21,23)
PubChem CID10809156
ChEMBLCHEMBL355135
IUPHARN/A
BindingDB50074416
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID10072680BindingDB,ChEMBL

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