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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameCHEMBL130850
Molecular formulaC14H25N3O2
IUPAC name3-(1H-imidazol-5-yl)propyl N-(2,4-dimethylpentan-3-yl)carbamate
Molecular weight267.373
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.5
SynonymsBDBM50409576
Inchi KeyDZINJPXLRDJYMP-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H25N3O2/c1-10(2)13(11(3)4)17-14(18)19-7-5-6-12-8-15-9-16-12/h8-11,13H,5-7H2,1-4H3,(H,15,16)(H,17,18)
PubChem CID11010982
ChEMBLCHEMBL130850
IUPHARN/A
BindingDB50409576
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<10.0 mg.kg-1PMID12190321ChEMBL

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