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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	MLS002157414
Molecular formula	C21H19N3O5S
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(6-methoxy-1,3-benzothiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
Molecular weight	425.459
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.3
Synonyms	AKOS001289177 SMR001239903 CHEMBL1395713 AKOS016861989 HMS3037I06 AB00750882-01 MolPort-003-322-920 MCULE-9080025072 [ Show all ]
Inchi Key	DZLMOMQAXUSPAG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H19N3O5S/c1-27-14-3-4-15-18(10-14)30-21(22-15)23-20(26)12-8-19(25)24(11-12)13-2-5-16-17(9-13)29-7-6-28-16/h2-5,9-10,12H,6-8,11H2,1H3,(H,22,23,26)
PubChem CID	16309570
ChEMBL	CHEMBL1395713
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	2310.9 nM	PubChem BioAssay data set	ChEMBL

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