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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL572588
Molecular formulaC16H19ClF2N4O3
IUPAC name5-chloro-3-[[6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl]amino]-1-[(2R)-1-methoxypropan-2-yl]pyrazin-2-one
Molecular weight388.8
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP2.9
SynonymsBDBM50300143
(R)-5-Chloro-3-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-1-(2-methoxy-1-methylethyl)pyrazin-2(1H)-one
Inchi KeyDZTDHMGXIRVSAW-SECBINFHSA-N
Inchi IDInChI=1S/C16H19ClF2N4O3/c1-8-5-11(10(3)20-14(8)26-16(18)19)21-13-15(24)23(6-12(17)22-13)9(2)7-25-4/h5-6,9,16H,7H2,1-4H3,(H,21,22)/t9-/m1/s1
PubChem CID44596587
ChEMBLCHEMBL572588
IUPHARN/A
BindingDB50300143
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501.6 nMPMID19954247BindingDB,ChEMBL

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