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GPCR

NameBeta-3 adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdrb3
Synonymbeta3-adrenoceptor
beta3-adrenergic receptor
Beta-3 adrenoreceptor
Beta-3 adrenoceptor
ADRB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
UniProtP26255
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4031
IUPHAR30
DrugBankN/A

Ligand

NameCHEMBL48227
Molecular formulaC23H30N2O6
IUPAC name2-[4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]phenoxy]-1-morpholin-4-ylethanone
Molecular weight430.501
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP1.4
Synonyms4-[[4-[2-[2-Hydroxy-3-(phenoxy)propylamino]ethoxy]phenoxy]acetyl]morpholine
Inchi KeyDZWLQNCRJOAATR-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H30N2O6/c26-19(17-30-20-4-2-1-3-5-20)16-24-10-13-29-21-6-8-22(9-7-21)31-18-23(27)25-11-14-28-15-12-25/h1-9,19,24,26H,10-18H2
PubChem CID15174953
ChEMBLCHEMBL48227
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
GDP ED500.54 mg kg-1PMID1350310ChEMBL

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