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Name | Histamine H3 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | CHEMBL1783896 |
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Molecular formula | C18H29N3O2 |
IUPAC name | 4-[[5-(3-piperidin-1-ylpropoxy)pyridin-2-yl]methyl]morpholine |
Molecular weight | 319.449 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 1.6 |
Synonyms | 4-[5-(3-piperidin-1-yl-propoxy)-pyridin-2-ylmethyl]-morpholine BDBM50346206 SCHEMBL1855803 |
Inchi Key | AKESFWSNMOFOQC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H29N3O2/c1-2-7-20(8-3-1)9-4-12-23-18-6-5-17(19-15-18)16-21-10-13-22-14-11-21/h5-6,15H,1-4,7-14,16H2 |
PubChem CID | 11638322 |
ChEMBL | CHEMBL1783896 |
IUPHAR | N/A |
BindingDB | 50346206 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 6.9 nM | PMID19577344 | BindingDB,ChEMBL |
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