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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	2-Benzylidene-1,2-dihydro-indol-3-one
Molecular formula	C15H11NO
IUPAC name	(2Z)-2-benzylidene-1H-indol-3-one
Molecular weight	221.259
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.6
Synonyms	HMS1678P12 AKFPHXCDBVJHSP-UVTDQMKNSA-N MolPort-001-975-341 2-(phenylmethylene)-1H-benzo[d]azolin-3-one ST080606 2-Benzylidene-1H-indole-3(2H)-one HMS2442O17 (2Z)-2-benzylidene-1H-indol-3-one AKOS024285055 SCHEMBL5695453 2-(Phenylmethylidene)-1H-indol-3-one CHEMBL1612834 ZINC3001673 AC1M591O MLS000551200 (Z)-2-Benzylideneindoline-3-one BAS 02171304 SMR000177424 [ Show all ]
Inchi Key	AKFPHXCDBVJHSP-UVTDQMKNSA-N
Inchi ID	InChI=1S/C15H11NO/c17-15-12-8-4-5-9-13(12)16-14(15)10-11-6-2-1-3-7-11/h1-10,16H/b14-10-
PubChem CID	2297827
ChEMBL	CHEMBL1612834
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	16360.1 nM	PubChem BioAssay data set	ChEMBL

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