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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gastric inhibitory polypeptide receptor
Species	Homo sapiens (Human)
Gene	GIPR
Synonym	GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr
Disease	Type 2 diabetes
Length	466
Amino acid sequence	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProt	P48546
Protein Data Bank	N/A
GPCR-HGmod model	P48546
3D structure model	This predicted structure model is from GPCR-EXP P48546.
BioLiP	N/A
Therapeutic Target Database	T41750
ChEMBL	CHEMBL4383
IUPHAR	248
DrugBank	N/A

Ligand

Name	aminothiazole, 13
Molecular formula	C32H29F6N3O3S
IUPAC name	3-[[4-[(N-[4-[3,5-bis(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-3-methyl-4-propan-2-ylanilino)methyl]benzoyl]amino]propanoic acid
Molecular weight	649.652
Hydrogen bond acceptor	12
Hydrogen bond donor	2
XlogP	8.2
Synonyms	CHEMBL502694 BDBM29116 SCHEMBL2648648
Inchi Key	FDAPJZJLEIYQAN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H29F6N3O3S/c1-18(2)26-9-8-25(12-19(26)3)41(16-20-4-6-21(7-5-20)29(44)39-11-10-28(42)43)30-40-27(17-45-30)22-13-23(31(33,34)35)15-24(14-22)32(36,37)38/h4-9,12-15,17-18H,10-11,16H2,1-3H3,(H,39,44)(H,42,43)
PubChem CID	22496546
ChEMBL	CHEMBL502694
IUPHAR	N/A
BindingDB	29116
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	584.0 nM	PMID19385613	BindingDB,ChEMBL

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