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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesCavia porcellus (Guinea pig)
GeneCYSLTR1
SynonymCysLTR1
Cysteinyl leukotriene D4 receptor
LTD4 receptor
DiseaseN/A for non-human GPCRs
Length340
Amino acid sequenceMDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProtQ2NNR5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5645
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL34740
Molecular formulaC25H15BrN2O5
IUPAC name6-bromo-4-oxo-2-[3-(quinazolin-2-ylmethoxy)phenyl]chromene-8-carboxylic acid
Molecular weight503.308
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.5
Synonyms2-[3-[(2-Quinazolinyl)methoxy]phenyl]-4-oxo-6-bromo-4H-1-benzopyran-8-carboxylic acid
6-Bromo-4-oxo-2-[3-(quinazolin-2-ylmethoxy)-phenyl]-4H-chromene-8-carboxylic acid
BDBM50064061
SCHEMBL6174551
6-bromo-4-oxo-2-(3-(quinazolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acid
Inchi KeyFEGCUSQYQHOKFE-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H15BrN2O5/c26-16-9-18-21(29)11-22(33-24(18)19(10-16)25(30)31)14-5-3-6-17(8-14)32-13-23-27-12-15-4-1-2-7-20(15)28-23/h1-12H,13H2,(H,30,31)
PubChem CID10839186
ChEMBLCHEMBL34740
IUPHARN/A
BindingDB50064061
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd101.0 nMPMID9554876BindingDB,ChEMBL

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