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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameSMR000006308
Molecular formulaC17H26N4O4S
IUPAC name[2-(tert-butylamino)-2-oxoethyl] 4-amino-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate
Molecular weight382.479
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP2.8
Synonyms4-amino-3-(cyclohexylcarbamoyl)isothiazole-5-carboxylic acid [2-(tert-butylamino)-2-keto-ethyl] ester
SR-01000328086
HMS2379D21
SR-01000328086-5
ASN 06264474
[ Show all ]
Inchi KeyFEQNTUXIYYKDDE-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H26N4O4S/c1-17(2,3)20-11(22)9-25-16(24)14-12(18)13(21-26-14)15(23)19-10-7-5-4-6-8-10/h10H,4-9,18H2,1-3H3,(H,19,23)(H,20,22)
PubChem CID646580
ChEMBLCHEMBL1392033
IUPHARN/A
BindingDB97055
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501955.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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