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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

Name(S)-zacopride
Molecular formulaC15H20ClN3O2
IUPAC name4-amino-N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2-methoxybenzamide
Molecular weight309.794
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.7
Synonyms4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide
D0I4BZ
UNII-9GN3OT4156 component FEROPKNOYKURCJ-CYBMUJFWSA-N
PDSP1_001634
4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((S)-methoxy)-benzamide
[ Show all ]
Inchi KeyFEROPKNOYKURCJ-CYBMUJFWSA-N
Inchi IDInChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m1/s1
PubChem CID6604914
ChEMBLCHEMBL28992
IUPHARN/A
BindingDB50056419
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.9 -Bioorg. Med. Chem. Lett., (1993) 3:6:1375ChEMBL
EC5055.9 nMBioorg. Med. Chem. Lett., (1996) 6:3:263ChEMBL
EC5056.0 nMN/ABindingDB
EC5063.0 nMN/ABindingDB
EC5063.1 nMBioorg. Med. Chem. Lett., (1993) 3:6:1375ChEMBL
EC50203.0 nM, Bioorg. Med. Chem. Lett., (1992) 2:12:1613BindingDB,ChEMBL
Ki131.0 nM, Bioorg. Med. Chem. Lett., (1996) 6:3:263BindingDB,ChEMBL
Ki383.0 nM, PMID9046352, Bioorg. Med. Chem. Lett., (1995) 5:8:795BindingDB,ChEMBL

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