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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameZacopride
Molecular formulaC15H20ClN3O2
IUPAC name4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide
Molecular weight309.794
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.7
Synonyms(RS)-Zacopride
4-amino-N-(1-azabicyclo(2,2,2)oct-3-yl)-5-chloro-2-methoxybenzamide-2-butenedioate
90182-92-6
CHEBI:91810
L001315
[ Show all ]
Inchi KeyFEROPKNOYKURCJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
PubChem CID108182
ChEMBLCHEMBL18041
IUPHAR245
BindingDB50000492
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki100.0 nMPMID9225293BindingDB
Ki125.89 nMPMID9225293BindingDB
Ki125.893 - 1258.93 nMPMID8813606, PMID9225293IUPHAR
Ki136.0 nMPMID8813606BindingDB
Ki158.0 nM, Bioorg. Med. Chem. Lett., (1996) 6:11:1195BindingDB,ChEMBL
Ki186.2 nMPMID9351641BindingDB
Ki316.0 nMPMID8226867BindingDB
Ki316.22 nMPMID9225293BindingDB
Ki753.0 nM, Bioorg. Med. Chem. Lett., (1994) 4:12:1433BindingDB,ChEMBL
Ki794.32 nMPMID9225293BindingDB
Ki808.0 nMPMID7796807, PMID8813606BindingDB
Ki1000.0 nMPMID9225293BindingDB
Ki1258.92 nMPMID9225293BindingDB

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