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GPCR

Name	Metabotropic glutamate receptor 6
Species	Homo sapiens (Human)
Gene	GRM6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A
Length	877
Amino acid sequence	MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
UniProt	O15303
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4573
IUPHAR	294
DrugBank	N/A

Ligand

Name	4815-28-5
Molecular formula	C9H12N2OS
IUPAC name	2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Molecular weight	196.268
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.9
Synonyms	A827486 AKOS000104415 Benzo[b]thiophene-3-carboxamide, 2-amino-4,5,6,7-tetrahydro- CTK4J0687 IFLab1_000769 MFCD00111277 RP25452 ST24039910 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide # ZINC35817 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide AC1L6DEZ ANW-59158 CA-1070 FFAKFORHXDNYEN-UHFFFAOYSA-N KB-19809 MolPort-000-149-006 SMR000059907 TR-017666 2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophen e-3-carboxylic acid amide 2-azanyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 4CH-023775 AE-848/01456023 BB 0217612 CHEMBL567508 HMS2208E10 KS-00004AEI Oprea1_259647 SR-01000403381-3 2-amino-3-carboxamido-4,5,6,7-tetrahydrobenzo[b]thiophene Z56757182 2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide AB0048892 ALBB-001594 Benzo[b]thiophene-3-carboxamide,2-amino-4,5,6,7-tetrahydro- EN300-02284 J-507810 MLS000057631 SBB000354 STK097175 2-amino-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxamide 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 400801-44-7 AC1Q4Z6U ARONIS018154 CCG-44089 FT-0677148 KB-93577 NSC-153313 SR-01000403381 2-amino-3-carbamoyl-4,5,6,7-tetrahydrobenzo[b]thiophene TRA0011651 2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophen-3-carboxamid 815A285 AK-45614 BBL004565 CS-D0059 I01-15770 MCULE-5059024267 Oprea1_680034 ST005598 2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide ZERO/005481 2-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxamide, AldrichCPR AB03445 AM807376 BS-4090 F0239-0077 K-9171 MLS000877452 SCHEMBL2688221 SY006711 2-Amino-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxamide, 97% 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amide AC1Q5D7N BAS 06761240 HMS1414C21 KS-00000B5C NSC153313 SR-01000403381-1 2-amino-3-carboxamido-4,5,6,7-tetrahydro benzo[b]thiophene V6139 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide [ Show all ]
Inchi Key	FFAKFORHXDNYEN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H12N2OS/c10-8(12)7-5-3-1-2-4-6(5)13-9(7)11/h1-4,11H2,(H2,10,12)
PubChem CID	290223
ChEMBL	CHEMBL567508
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	13.0 %	PMID19819046	ChEMBL

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