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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL573792 |
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Molecular formula | C23H25Cl2N7O3 |
IUPAC name | N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-1-(4-nitrophenyl)triazole-4-carboxamide |
Molecular weight | 518.399 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.4 |
Synonyms | BDBM50298911 N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-1-(4-nitrophenyl)-1H-[1,2,3]triazol-4-carboxamide |
Inchi Key | FFDHLEGSHFJYQA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H25Cl2N7O3/c24-19-4-3-5-21(22(19)25)30-14-12-29(13-15-30)11-2-1-10-26-23(33)20-16-31(28-27-20)17-6-8-18(9-7-17)32(34)35/h3-9,16H,1-2,10-15H2,(H,26,33) |
PubChem CID | 45482152 |
ChEMBL | CHEMBL573792 |
IUPHAR | N/A |
BindingDB | 50298911 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 33.0 % | PMID19592258 | ChEMBL |
Activity | 53.0 % | PMID19592258 | ChEMBL |
Ki | 17.0 nM | PMID19592258 | BindingDB,ChEMBL |
Ki | 810.0 nM | PMID19592258 | BindingDB,ChEMBL |
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