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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL1083590
Molecular formulaC17H20F3N5O2
IUPAC name1-(1-cyclopropylpropyl)-5-[[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]amino]-3-methyl-1,2,4-triazin-6-one
Molecular weight383.375
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP2.8
SynonymsBDBM50320252
1-(1-cyclopropylpropyl)-5-(6-methoxy-2-(trifluoromethyl)pyridin-3-ylamino)-3-methyl-1,2,4-triazin-6(1H)-one
Inchi KeyFFWHWKFBSHLABO-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H20F3N5O2/c1-4-12(10-5-6-10)25-16(26)15(21-9(2)24-25)22-11-7-8-13(27-3)23-14(11)17(18,19)20/h7-8,10,12H,4-6H2,1-3H3,(H,21,22,24)
PubChem CID46891231
ChEMBLCHEMBL1083590
IUPHARN/A
BindingDB50320252
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC503.7 nMPMID20483614BindingDB,ChEMBL

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