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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	CHEMBL1777862
Molecular formula	C19H14ClNO3
IUPAC name	3-[4-(2-chloro-4-cyanophenoxy)phenyl]hex-4-ynoic acid
Molecular weight	339.775
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BDBM50344069 rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-ynoic acid
Inchi Key	FGWIQWCSFPANHU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14ClNO3/c1-2-3-15(11-19(22)23)14-5-7-16(8-6-14)24-18-9-4-13(12-21)10-17(18)20/h4-10,15H,11H2,1H3,(H,22,23)
PubChem CID	54586484
ChEMBL	CHEMBL1777862
IUPHAR	N/A
BindingDB	50344069
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	42.0 nM	PMID21514824	BindingDB,ChEMBL
EC50	519.0 nM	PMID21514824	BindingDB,ChEMBL
EC50	597.0 nM	PMID21514824	BindingDB,ChEMBL
IC50	23.0 nM	PMID21514824	BindingDB,ChEMBL

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