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Name | Sphingosine 1-phosphate receptor 1 |
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Species | Homo sapiens (Human) |
Gene | S1PR1 |
Synonym | Sphingosine 1-phosphate receptor Edg-1 S1P1 receptor S1P1 S1P receptor Edg-1 S1P receptor 1 [ Show all ] |
Disease | Immune disorder Macular degeneration Hepatocellular carcinoma; Multiple scierosis Multiple scierosis Primary progressive multiple sclerosis [ Show all ] |
Length | 382 |
Amino acid sequence | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS |
UniProt | P21453 |
Protein Data Bank | 3v2w |
GPCR-HGmod model | P21453 |
3D structure model | This structure is from PDB ID 3v2w. |
BioLiP | BL0214678 |
Therapeutic Target Database | T13852 |
ChEMBL | CHEMBL4333 |
IUPHAR | 275 |
DrugBank | N/A |
Name | MLS000056228 |
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Molecular formula | C12H11N3S2 |
IUPAC name | N-methyl-N-(thiophen-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine |
Molecular weight | 261.361 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 3.0 |
Synonyms | AC1M913T methyl-(2-thenyl)-thieno[2,3-d]pyrimidin-4-yl-amine Z31140431 N-methyl-N-(thiophen-2-ylmethyl)-4-thieno[2,3-d]pyrimidinamine HMS2353H06 [ Show all ] |
Inchi Key | AKRBRYDOJWGQRX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H11N3S2/c1-15(7-9-3-2-5-16-9)11-10-4-6-17-12(10)14-8-13-11/h2-6,8H,7H2,1H3 |
PubChem CID | 2524807 |
ChEMBL | CHEMBL1612194 |
IUPHAR | N/A |
BindingDB | 36969 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <30000.0 nM | N/A | BindingDB |
EC50 | 13000.0 nM | N/A | BindingDB |
EC50 | 14160.0 nM | N/A | BindingDB |
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