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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL2386357
Molecular formulaC16H13NO2
IUPAC name3-[6-(2-phenylethynyl)pyridin-3-yl]propanoic acid
Molecular weight251.285
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.7
SynonymsBDBM50434310
Inchi KeyAKRJMXPWEDZRLB-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H13NO2/c18-16(19)11-8-14-7-10-15(17-12-14)9-6-13-4-2-1-3-5-13/h1-5,7,10,12H,8,11H2,(H,18,19)
PubChem CID71655226
ChEMBLCHEMBL2386357
IUPHARN/A
BindingDB50434310
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC502511.89 nMPMID23687558ChEMBL
EC502512.0 nMPMID23687558BindingDB
Efficacy99.0 %PMID23687558ChEMBL

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