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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameAla8,Ava14,15
Molecular formulaC50H83N17O12S2
IUPAC name31-[[2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-19-[3-(diaminomethylideneamino)propyl]-13-[(4-hydroxyphenyl)methyl]-28-methyl-25-(2-methylpropyl)-6,12,15,18,21,24,27,30-octaoxo-16-propan-2-yl-1,2-dithia-5,11,14,17,20,23,26,29-octazacyclodotriacontane-4-carboxamide
Molecular weight1178.44
Hydrogen bond acceptor16
Hydrogen bond donor16
XlogP-2.7
SynonymsBDBM85969
Inchi KeyFIPPSVSXLHDCBJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C50H83N17O12S2/c1-26(2)21-34-44(75)59-23-39(71)62-33(12-10-20-58-50(54)55)46(77)67-40(27(3)4)48(79)65-35(22-30-14-16-31(69)17-15-30)43(74)56-18-8-7-13-38(70)63-36(41(51)72)24-80-81-25-37(47(78)60-28(5)42(73)64-34)66-45(76)32(61-29(6)68)11-9-19-57-49(52)53/h14-17,26-28,32-37,40,69H,7-13,18-25H2,1-6H3,(H2,51,72)(H,56,74)(H,59,75)(H,60,78)(H,61,68)(H,62,71)(H,63,70)(H,64,73)(H,65,79)(H,66,76)(H,67,77)(H4,52,53,57)(H4,54,55,58)
PubChem CID57340396
ChEMBLN/A
IUPHARN/A
BindingDB85969
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki38.0 nMPMID12009900BindingDB

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