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GPCR

NameAdenosine receptor A1
SpeciesRattus norvegicus (Rat)
GeneAdora1
SynonymA1 receptor
A1-AR
A1R
adenosine receptor A1
RDC7
DiseaseN/A for non-human GPCRs
Length326
Amino acid sequenceMPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
UniProtP25099
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL318
IUPHAR18
DrugBankN/A

Ligand

NameXanthine amine congener
Molecular formulaC21H28N6O4
IUPAC nameN-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Molecular weight428.493
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP2.7
SynonymsAC1L1KXN
D09HUM
Lopac-X-103
N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide hydrochloride
NCGC00094514-01
[ Show all ]
Inchi KeyFIQGIOAELHTLHM-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)
PubChem CID5697
ChEMBLCHEMBL273094
IUPHAR404, 432
BindingDB50207816
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.49 nMPMID2067592BindingDB
Ki1.1 nMPMID2709373BindingDB,ChEMBL
Ki1.2 nMPMID3806597, PMID1738138, PMID11262085, PMID2754711, PMID1613758, PMID7932565, PMID1501234, PMID10737749, PMID2993622BindingDB,ChEMBL
Ki1.3 nMPMID11906291BindingDB,ChEMBL
Ki2.0 nMPMID1857334BindingDB
Ki3.5 nMPMID2825043BindingDB
Ki4.4 nMPMID2825043BindingDB
Ki24.0 nMPMID2825043BindingDB

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