You can:
Name | Melanin-concentrating hormone receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL210343 |
---|---|
Molecular formula | C32H33Cl2N3O |
IUPAC name | 3-[4-[4-(3-cyanophenyl)phenyl]-1-cyclopentylpiperidin-4-yl]-N-(3,5-dichlorophenyl)propanamide |
Molecular weight | 546.536 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 7.5 |
Synonyms | BDBM50186816 3-[4-(3''-cyano-biphenyl-4-yl)-1-cyclopentyl-piperidin-4-yl]-N-(3,5-dichloro-phenyl)-propionamide |
Inchi Key | FKTRDONUASUZHX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H33Cl2N3O/c33-27-19-28(34)21-29(20-27)36-31(38)12-13-32(14-16-37(17-15-32)30-6-1-2-7-30)26-10-8-24(9-11-26)25-5-3-4-23(18-25)22-35/h3-5,8-11,18-21,30H,1-2,6-7,12-17H2,(H,36,38) |
PubChem CID | 20608976 |
ChEMBL | CHEMBL210343 |
IUPHAR | N/A |
BindingDB | 50186816 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 42.0 nM | PMID16690312 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218