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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesSus scrofa (Pig)
GeneHTR4
Synonym5-HT-4
5-HT4
Serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length137
Amino acid sequenceCCQPLVYRNKMTPLRVAVLLAGCWAIPVLISFLPIMQGWNNIGITDLIEKRKFHQNSNSTYCIFMVNKPYAITCSVVAFYIPFLLMVLAYWRIYVTAKEHAHQIQMLQRAGAPAEGRPPSADQHSTHRMRTETKAAK
UniProtQ29006
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

NameBW-723C86
Molecular formulaC16H18N2OS
IUPAC name1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]propan-2-amine
Molecular weight286.393
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.0
Synonyms1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]propan-2-amine
BRD-A17428743-001-01-1
CHEMBL1255834
NCGC00015135-05
AC1N7TG2
[ Show all ]
Inchi KeyALFGDCNSEBJYSP-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3
PubChem CID4284720
ChEMBLCHEMBL1255834
IUPHAR161
BindingDB82472
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID8788493BindingDB

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