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Name | Neuromedin-B receptor |
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Species | Homo sapiens (Human) |
Gene | NMBR |
Synonym | BB1 receptor Epididymis tissue protein Li 185a BB1 neuromedin-B-preferring bombesin receptor NMB-R [ Show all ] |
Disease | N/A |
Length | 390 |
Amino acid sequence | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL |
UniProt | P28336 |
Protein Data Bank | N/A |
GPCR-HGmod model | P28336 |
3D structure model | This predicted structure model is from GPCR-EXP P28336. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3636 |
IUPHAR | 38 |
DrugBank | N/A |
Name | BDBM50295224 |
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Molecular formula | C21H20ClFN2O |
IUPAC name | 6-(2-chloro-6-fluorophenyl)-3,9-dimethyl-5,6,6a,8,9,10-hexahydrobenzo[b][1,4]benzodiazepin-7-one |
Molecular weight | 370.852 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | 11-(2-chloro-6-fluorophenyl)-3,8-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one |
Inchi Key | FMSPMCATPJWWEM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H20ClFN2O/c1-11-6-7-15-16(8-11)25-21(19-13(22)4-3-5-14(19)23)20-17(24-15)9-12(2)10-18(20)26/h3-8,12,20-21,25H,9-10H2,1-2H3 |
PubChem CID | 91934295 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50295224 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 450.0 nM | PMID19553112 | BindingDB |
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