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GPCR

NameBeta-3 adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdrb3
Synonymbeta3-adrenoceptor
beta3-adrenergic receptor
Beta-3 adrenoreceptor
Beta-3 adrenoceptor
ADRB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
UniProtP26255
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4031
IUPHAR30
DrugBankN/A

Ligand

NameCHEMBL1743907
Molecular formulaC20H25ClFNO6
IUPAC namemethyl 2-[4-[2-[[3-(2-fluorophenoxy)-2-hydroxypropyl]amino]ethoxy]phenoxy]acetate;hydrochloride
Molecular weight429.869
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogPNone
SynonymsSCHEMBL10346668
Inchi KeyFNFLJZXBEQSOKB-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24FNO6.ClH/c1-25-20(24)14-27-17-8-6-16(7-9-17)26-11-10-22-12-15(23)13-28-19-5-3-2-4-18(19)21;/h2-9,15,22-23H,10-14H2,1H3;1H
PubChem CID22154116
ChEMBLCHEMBL1743907
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
ED500.15 mg.kg-1PMID1350309ChEMBL
ED500.54 mg.kg-1PMID1350309ChEMBL
SI<100.0 beats min-1PMID1350309ChEMBL

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