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GPCR

NameType-1B angiotensin II receptor
SpeciesRattus norvegicus (Rat)
GeneAgtr1b
SynonymAngiotensin II type-1B receptor
AT1B
AT3
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
UniProtP29089
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL86346
Molecular formulaC23H22N8
IUPAC name2-ethyl-5,7-dimethyl-3-[[4-[3-(2H-tetrazol-5-yl)pyridin-2-yl]phenyl]methyl]imidazo[4,5-b]pyridine
Molecular weight410.485
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.7
SynonymsBDBM50145960
SCHEMBL9701759
2-Ethyl-5,7-dimethyl-3-{4-[3-(2H-tetrazol-5-yl)-pyridin-2-yl]-benzyl}-3H-imidazo[4,5-b]pyridine
Inchi KeyFNZWHLOBAMJQLV-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H22N8/c1-4-19-26-20-14(2)12-15(3)25-23(20)31(19)13-16-7-9-17(10-8-16)21-18(6-5-11-24-21)22-27-29-30-28-22/h5-12H,4,13H2,1-3H3,(H,27,28,29,30)
PubChem CID19889373
ChEMBLCHEMBL86346
IUPHARN/A
BindingDB50145960
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5018.0 nMPMID15115399BindingDB,ChEMBL

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