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Name | Motilin receptor |
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Species | Homo sapiens (Human) |
Gene | MLNR |
Synonym | GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR [ Show all ] |
Disease | Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder [ Show all ] |
Length | 412 |
Amino acid sequence | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG |
UniProt | O43193 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43193 |
3D structure model | This predicted structure model is from GPCR-EXP O43193. |
BioLiP | N/A |
Therapeutic Target Database | T62306 |
ChEMBL | CHEMBL2203 |
IUPHAR | 297 |
DrugBank | BE0003521 |
Name | CHEMBL396413 |
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Molecular formula | C30H40F3N7O4 |
IUPAC name | 2-[[(6R,9R,12S)-7,10,13-trioxo-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]methyl]guanidine |
Molecular weight | 619.69 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 6 |
XlogP | 2.6 |
Synonyms | BDBM50214264 SCHEMBL13392340 1-{[(5R,8R,11S)-6,9,12-trioxo-8-(propan-2-yl)-5-{[3-(trifluoromethyl)phenyl]methyl}-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-1,4,7,10,13-benzoxatetrazacyclooctadecin-11-yl]methyl}guanidine |
Inchi Key | FOPMEOGNSDLKOM-GIFXNVAJSA-N |
Inchi ID | InChI=1S/C30H40F3N7O4/c1-18(2)25-28(43)39-23(17-38-29(34)35)26(41)37-12-6-9-20-8-3-4-11-24(20)44-14-13-36-22(27(42)40-25)16-19-7-5-10-21(15-19)30(31,32)33/h3-5,7-8,10-11,15,18,22-23,25,36H,6,9,12-14,16-17H2,1-2H3,(H,37,41)(H,39,43)(H,40,42)(H4,34,35,38)/t22-,23+,25-/m1/s1 |
PubChem CID | 44432977 |
ChEMBL | CHEMBL396413 |
IUPHAR | N/A |
BindingDB | 50214264 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 28.0 nM | PMID17533127 | BindingDB,ChEMBL |
Ki | 6.0 nM | PMID17533127 | BindingDB,ChEMBL |
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