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GPCR

NameBeta-2 adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdrb2
Synonymbeta2-adrenoceptor
Beta-2 adrenoreceptor
Beta-2 adrenoceptor
beta-2 adrenergic receptor
beta 2-AR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length418
Amino acid sequenceMEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
UniProtP10608
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3754
IUPHAR29
DrugBankN/A

Ligand

NameCHEMBL287587
Molecular formulaC8H10FNO3
IUPAC name4-(2-amino-1-hydroxyethyl)-3-fluorobenzene-1,2-diol
Molecular weight187.17
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP-0.5
Synonyms4-(2-Amino-1-hydroxyethyl)-3-fluoro-1,2-benzenediol #
2-Fluoronorepinephrine
71144-40-6
4-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-diol
Benzenethanamine, 2-fluoro-.beta.,3,4-trihydroxy-
[ Show all ]
Inchi KeyFOTRTWXNJQSQJS-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H10FNO3/c9-7-4(6(12)3-10)1-2-5(11)8(7)13/h1-2,6,11-13H,3,10H2
PubChem CID172745
ChEMBLCHEMBL287587
IUPHARN/A
BindingDB50019060
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1500.0 nMPMID8254623BindingDB,ChEMBL

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