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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameEticlopride
Molecular formulaC17H25ClN2O3
IUPAC name5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight340.848
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.1
Synonyms3-Chloro-5-Ethyl-N-{[(2s)-1-Ethylpyrrolidin-2-Yl]methyl}-6-Hydroxy-2-Methoxybenzamide
AC1L1MN4
CHEBI:92874
Eticlopride [INN]
GTPL966
[ Show all ]
Inchi KeyAADCDMQTJNYOSS-LBPRGKRZSA-N
Inchi IDInChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1
PubChem CID57267
ChEMBLCHEMBL8946
IUPHAR966
BindingDB50007518
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Change-18.0 %PMID12723940ChEMBL
Change-14.0 %PMID12723940ChEMBL
Change24.0 %PMID12723940ChEMBL
IC500.92 nMPMID1969484BindingDB
IC500.92 nMPMID7901417, PMID1969484, PMID1672158BindingDB,ChEMBL
Kd0.17 nMPMID2966245, PMID2136916BindingDB,ChEMBL
Ki0.02 nMPMID8301592BindingDB
Ki0.04 nMPMID2531826BindingDB
Ki0.06 nMPMID8301592BindingDB
Ki0.07 nMPMID10327430BindingDB
Ki0.09 nMPMID8093734BindingDB,ChEMBL
Ki0.12 nMPMID1969484BindingDB,ChEMBL
Ki0.19 nMPMID1827843BindingDB,ChEMBL
Ki0.22 nMPMID10327430BindingDB
Ki0.31 nMPMID2869639BindingDB
Ki0.79 nMPMID10327430BindingDB
Ki0.92 nMPMID2869639BindingDB
Ki0.99 nMPMID1827843ChEMBL
Ki0.99 nMPMID1827843BindingDB
Ki1.6 nMPMID2869639BindingDB

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